期刊
TETRAHEDRON LETTERS
卷 53, 期 18, 页码 2280-2283出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.02.063
关键词
Penicillium sp.; Alkaloids; Antifouling
资金
- National Basic Research Program of China [2010CB833803]
- National Natural Science Foundation of China [40931160435, 40976090, 20872151]
- Chinese Academy of Science [KSCX2-EW-G-12B, 5060267]
Penispirolloid A (1), a novel alkaloid possessing a unique Spiro imidazolidinyl skeleton, was isolated from a halotolerant fungal strain. Penicillium sp. OUCMDZ-776. Its structure was elucidated on the basis of spectroscopic methods and quantum chemical CD calculation. Compound 1 showed significant antifouling activity toward Bugula neritina larvae with EC50 of 2.40 mu g/ml. Plausible biogenesis of compound 1 was also proposed. (C) 2012 Elsevier Ltd. All rights reserved.
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