期刊
TETRAHEDRON LETTERS
卷 53, 期 23, 页码 2850-2855出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.03.116
关键词
Macrocycles; Peptidotriazoles; Click chemistry; Multi-component reactions; Step economy
A two-step macrocyclization strategy for the synthesis of 12- and 14-membered cyclic peptidotriazoles by combining a one pot four-component reaction and an intramolecular [3+2] azide-alkyne click cyclo-addition reaction is described. Macrocycles are obtained in good to excellent yield from the aqueous work-up of the reaction mixture and it is possible to expand or contract the ring size by adjusting the length of the nitrile moiety used in the MCR stage. (C) 2012 Elsevier Ltd. All rights reserved.
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