期刊
TETRAHEDRON LETTERS
卷 53, 期 52, 页码 7083-7084出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.10.066
关键词
Parazoanthine; Hydantoin; Chemical synthesis
资金
- PRIN-MIUR Project 'Prodotti naturali da molluschi opistobranchi: identificazione di nuovi lead compounds per lo sviluppo di farmaci antitumorali'
Parazoanthine A (7.0% overall yield) and its O-methyl derivative (6.2% overall yield) were prepared by a concise biomimetic synthesis based on the coupling reaction of L-arginine methyl ester dihydrochloride with isocyanate derivatives of p-coumaric acid and 4-methoxy-cinnamic acid, respectively. The synthetic approach is designed to obtain a wider class of parazoanthine analogs. (C) 2012 Elsevier Ltd. All rights reserved.
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