期刊
TETRAHEDRON LETTERS
卷 53, 期 18, 页码 2298-2301出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.02.095
关键词
Multicomponent reactions; Heterocycles; Palladium catalysis; Copper catalysis; Triazines; Indazolones; Ugi reaction; Hydroxytriazafluorendione
Indazolones are medicinally relevant targets. Herein we disclose an improved synthesis to N'-(acetamido-2-yl)substituted indazolones with four points of diversity introduced by Ugi-[M]-amination and -amidation. The ring closure can be achieved by either conventional palladium catalysis or with a ligandless copper protocol. When alpha-unbranched isocyanides were employed the sole cyclization products of the copper catalyzed reactions are the hitherto undescribed 2-hydroxy-3H-3,4a,9a-triaza-fluorene-4,9-diones. (C) 2012 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据