4′-Methylbiphenyl-2-carbonitrile synthesis by continuous flow Suzuki-Miyaura reaction

In the present work we report a high selective synthesis of the bicyclic core present in an important angiotensin II inhibitor family of drugs (Sartans) under continuous flow conditions. The key step in our approach was a Suzuki-Miyaura coupling using for the first time the recently described 4-toluylboronic acid MIDA ester. (C) 2012 Elsevier Ltd. All rights reserved.