期刊
TETRAHEDRON LETTERS
卷 53, 期 9, 页码 1063-1065出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.12.064
关键词
Benzothiazine ansamycin; Marine-derived Streptomyces; Herbimycin A; Natural products chemistry
资金
- Institute for Molecular Bioscience
- University of Queensland
- Australian Research Council [LP0989954]
- Australian Research Council [LP0989954] Funding Source: Australian Research Council
Chemical analysis of a marine-derived Streptomyces sp. (CMB-M0392) isolated from sediment collected off Heron Island, Queensland, Australia, yielded a new benzothiazine ansamycin, heronamycin A. The absolute stereostructure of heronamycin A was determined by detailed spectroscopic analysis and Xray crystallography. Heronamycin A exhibited modest antimicrobial activity against Bacillus subtilis strains ATCC 6051 and 6633 (IC50 = 18 and 14 mu M, respectively). (C) 2011 Elsevier Ltd. All rights reserved.
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