期刊
TETRAHEDRON LETTERS
卷 52, 期 52, 页码 7125-7127出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.10.106
关键词
Indole alkaloids; Hunteria umbellata; Nigerian medicinal plant; Natural products chemistry
资金
- Nigerian Science and Technology Education Post - Basic (Step B)
- Education Trust
- Federal Ministry of Education, Nigeria
- University of Queensland
- Institute for Molecular Bioscience, The University of Queensland
- Australian Research Council [LP0989954]
- Australian Research Council [LP0989954] Funding Source: Australian Research Council
Chemical investigations into samples of Hunteria umbellata (K. Schum) collected in Osun State, Nigeria, led to the discovery of a new indole alkaloid, ikirydinium A, featuring an unprecedented 3-alkylpyridinium-indole-2-carboxylate scaffold. Ikirydinium A was found to exhibit antimicrobial activity (IC50 0.6 mu M) against Bacillus subtilis ATCC 6051. The involvement of a common intermediate in the biosynthesis of ikirydinium A and vinblastine is hypothesized. (C) 2011 Elsevier Ltd. All rights reserved.
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