期刊
TETRAHEDRON LETTERS
卷 52, 期 18, 页码 2387-2389出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.02.099
关键词
Click chemistry; Spirochromones; Antitubercular activity; Mycobacterium tuberculosis
资金
- Department of Science and Technology, Govt. of India [SR/FTP/CS-25/2007]
A series of novel 1,2,3-triazole fused spirochromone conjugates have been synthesized bearing both spirochromone moiety as well as a 1,2,3-triazole moiety. Some of the compounds have exhibited potential activity against Mycobacterium tuberculosis (virulent strain H37Rv). In particular 5e proved to be the most potent derivative exhibiting MIC = 0.78 mu g/mL. (C) 2011 Elsevier Ltd. All rights reserved.
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