Efficient one-pot synthesis of functionalized piperidine scaffolds via ZrOCl2•8H2O catalyzed tandem reactions of aromatic aldehydes with amines and acetoacetic esters

A highly efficient diastereoselective one-pot synthesis of functionalized piperidines has been developed based on an aqua-compatible ZrOCl2 center dot 8H(2)O catalyst via tandem reactions of aromatic aldehydes, amines, and acetoacetic esters. (C) 2011 Elsevier Ltd. All rights reserved.