期刊
TETRAHEDRON LETTERS
卷 52, 期 46, 页码 6094-6097出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.09.016
关键词
Nakadomarin A; Total synthesis; Organocatalysis; Stereoselective synthesis; Michael addition; Nitro-Mannich reaction; Iminium ion; Alkyne ring-closing metathesis; Cascade
资金
- EPSRC
- GlaxoSmithKline
- EPSRC [EP/G007802/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/G007802/1] Funding Source: researchfish
A 13-step, highly stereoselective synthesis of (-)-nakadomarin A has been achieved using the combination of a bifunctional organocatalyst controlled Michael addition, a nitro-Mannich/lactamization cascade, an alkyne ring-closing metathesis/syn-reduction, and furan/iminium ion cyclization/reduction as key steps. (C) 2011 Elsevier Ltd. All rights reserved.
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