期刊
TETRAHEDRON LETTERS
卷 52, 期 38, 页码 4967-4970出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.07.099
关键词
Alternative propargylic amine synthesis; Copper-catalyzed; AHA coupling
资金
- Institute of Bioengineering and Nanotechnology (Biomedical Research Council, Agency for Science, Technology and Research, Singapore)
A method for the synthesis of propargylic amines has been developed via an efficient copper(I)-catalyzed three-component coupling reaction of alkynes, benzal halides and amines through C-H and C-halogen activation. This reaction is conducted under mild conditions and provides an alternative method for the synthesis of propargylic amines. (C) 2011 Elsevier Ltd. All rights reserved.
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