期刊
TETRAHEDRON LETTERS
卷 52, 期 17, 页码 2165-2168出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.11.133
关键词
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资金
- National Institutes of Health [GM63167]
- Eli Lilly Research Laboratories
- Johnson Johnson PRI
The development of an effective protocol for the palladium-catalyzed cross-coupling of (E)-alkenylsilanols with aryl triflates is described. A critical component in the optimization of this method was balancing the stability and reactivity of the triflates in the presence of a nucleophilic promoter. This report highlights the use of a slightly soluble Bronsted base promoter that allows for a low, steady-state concentration of alkenyl(dimethyl)silanolate in solution, thus facilitating cross-coupling in preference to S-O bond cleavage of the triflate. (C) 2010 Elsevier Ltd. All rights reserved.
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