An organocatalyzed facile and rapid access to α-hydroxy and α-amino phosphonates under conventional/ultrasound technique

In the present work, successful implementation of ultrasound irradiation for the rapid synthesis of alpha-hydroxy and alpha-amino phosphonates under solvent-free conditions is demonstrated. Use of a novel catalyst (i.e., camphor sulfonic acid) in combination with ultrasound technique is reported for the first time. Comparative study for the synthesis of alpha-hydroxy and alpha-amino phosphonates using conventional as well as ultrasonication method is discussed. (C) 2011 Elsevier Ltd. All rights reserved.