A facile strategy for the one pot multicomponent synthesis of spiro dihydropyridines from amines and activated alkynes

An efficient preparation of a series of Spiro dihydropyridines via one pot four-component reactions of mono/di/tri-ketones, malononitrile, primary amines, and acetylenic esters is reported. The reaction is atom-efficient, high yielding, and follows a simple experimental procedure. (C) 2011 Elsevier Ltd. All rights reserved.