期刊
TETRAHEDRON LETTERS
卷 52, 期 16, 页码 1878-1881出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.02.031
关键词
Green synthesis; Multicomponent reactions; 4H-Pyran derivatives; Polysubstituted anilines; Silica nanoparticles
资金
- Office of Science, Office of Biological & Environmental Research, Biological Systems Science Division, of the U.S. Department of Energy [DE-FG02-08ER64624]
- NSF NPURC [0532242]
- EPSCoR
- Office Of The Director [0903804] Funding Source: National Science Foundation
A one-pot practical, efficient, and environmentally benign multicomponent synthesis of 4H-pyrans and polysubstituted aniline derivatives of biological, pharmacological, and optical applications has been developed using a very mild, neutral, and reusable silica nanoparticles as catalyst. The 4H-pyran derivatives were synthesized by a three component reaction of an aldehyde, malononitrile, and 5,5-dimethyl-1,3-cyclohexanedione or ethyl acetoacetate at room temperature or refluxing in ethanol. Alternatively, polysubstituted anilines were synthesized via a four component reaction of an aldehyde, a ketone, and two equivalents of malononitrile in ethanol. (C) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据