PdII/IV catalyzed oxidative cyclization of 1,6-enynes derived by Ugi-4-component reaction

A variety of 1,6-enynes were synthesized by an Ugi-reaction and further elaborated by a Pd-II/IV catalyzed oxidative cyclization to produce N-substituted 3-aza-bicyclo[3.1.0]hexan-2-ones. Different substitution patterns were tested to examine the scope and limitations of the amide tethered substrates. (C) 2011 Elsevier Ltd. All rights reserved.