期刊
TETRAHEDRON LETTERS
卷 52, 期 44, 页码 5728-5732出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.08.119
关键词
TLR7; Negishi; Carbamates; Heterocycles
A flexible route which enables access to derivatives of 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-ones is described. Issues of selectivity, reaction safety, and low yields in original routes are overcome with the key improvements to the route, including a Negishi cross-coupling and use of a carbamate as a protecting group and intrinsic carbonyl source. The new route enables variation of C-6 and N-1 substituents. (C) 2011 Elsevier Ltd. All rights reserved.
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