期刊
TETRAHEDRON LETTERS
卷 52, 期 34, 页码 4473-4477出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.06.070
关键词
2,6-Unsubstituted dihydropyridine; DHP; Ytterbium catalyst; Multi-component coupling reaction
资金
- 'Center for Practical Chemical Wisdom' by MEXT
- Waseda University [2010A-874]
The reaction of anilines, benzaldehydes. and ethyl 3,3-diethoxypropionate in the presence of Yb(OTf)(3) proceeded under mild reaction conditions to give dihydropyridines (DHPs). We have found that the reaction depended on the solvent and the DHPs were obtained selectively in 1,4-dioxane as a solvent. Various 2,6-unsubstituted DHPs were synthesized in one pot in satisfactory yields. (C) 2011 Elsevier Ltd. All rights reserved.
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