One-pot synthesis of 4,5-disubstituted 1,2,3-(NH)-triazoles using terminal acetylenes, carbon monoxide, aryl iodides, and sodium azide

A one-pot method for the synthesis of 4,5-disubstituted-1,2,3-(NH)-triazoles via carbonylative Sonogashira reaction/1,3-dipolar cycloaddition of terminal acetylenes, carbon monoxide, aryl iodides, and sodium azide was developed. A series of new 4,5-disubstituted-1,2,3-(NH)-triazoles were prepared readily under mild conditions. (C) 2010 Elsevier Ltd. All rights reserved.