Unusual ligand-dependent chemoselective Suzuki-Miyaura cross-coupling reactions of 3-bromo-4-trifloyl-thiophenes

An unusual ligand-dependent chemoselective Suzuki-Miyaura cross-coupling reaction for 3-bromo-4-trifloyl-thiophenes was discovered. Pd(PPh3)(4) showed selectivity for triflate over bromide, whereas the selectivity was reversed for Pd((Bu3P)-Bu-t)(2). (C) 2011 Elsevier Ltd. All rights reserved.