Hesseltins B-G, novel meroterpenoids from a new Penicillium species

Six new meroterpenoid compounds. hesseltins B-G, were isolated from Penicillium species along with the previously described hesseltin A. A further 14 compounds, which turned out to be photoisomers, were detected during purification and were subsequently isolated. The structures of these analogues were elucidated by comparison of their NMR spectral data with that of hesseltin A. None of the new hesseltins showed antiviral activity in a Herpes simplex virus type 2 assay. (C) 2010 Elsevier Ltd. All rights reserved.