期刊
TETRAHEDRON LETTERS
卷 52, 期 20, 页码 2597-2600出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.03.061
关键词
Green chemistry; Multi-component reaction; 4-Hydroxyquinolin-2(1H)-one; Aldehyde; Malononitrile
资金
- Chinese National Science and Technology Major Project 'Key New Drug Creation and Manufacturing Program' [2009ZX09301-001, 2009ZX09102-022]
- National Natural Science Foundation of China [21002027, 90713046, 30772638, 30925040]
- CAS Foundation [KSCX2-YW-R-179]
A green, efficient, and rapid procedure for the synthesis of 2-amino-3-cyano-1,4,5,6-tetrahydropyrano[3,2-c]quinolin-5-one derivatives has been developed by one-pot condensation of 4-hydroxyquinolin-2(1H)-one, aldehyde, and malononitrile in the presence of ammonium acetate in EtOH. This method has the advantages of operational simplicity, mild reaction conditions, short reaction time, and little environmental impact. (C) 2011 Elsevier Ltd. All rights reserved.
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