期刊
TETRAHEDRON LETTERS
卷 52, 期 48, 页码 6355-6358出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.09.031
关键词
Cross-coupling; Palladacycle; Sonogashira; Sustainability
资金
- KAUST
A thorough study on copper-free Sonogashira cross-couplings in water was carried out using the palladacycle, [{Pd(mu-Cl){kappa(2)-P,C-P(Pr-i)(2)(OC6H3-2-Ph)}}(2)] as pre-catalyst with different bases and palladium concentrations. The highly active pre-catalyst imparts good to near quantitative yields using a concentration of 0.25 mol % at 40 degrees C. This broadly applicable protocol exhibits high tolerance of functional groups and substitution patterns. (C) 2011 Elsevier Ltd. All rights reserved.
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