An efficient copper(II)-catalyzed synthesis of benzothiazoles through intramolecular coupling-cyclization of N-(2-chlorophenyl)benzothioamides

A wide range of 2-aryl or 2-alkyl-substituted benzothiazoles are synthesized through intramolecular C-(aryl)-S bond forming-cyclization using copper(II)-BINAM-catalyzed coupling of less reactive N-(2-chlorophenyl)benzo or alkylthioamide under mild reaction conditions (82 degrees C). (C) 2010 Elsevier Ltd. All rights reserved.