Indium(III) bromide-catalyzed hydroarylation of alkynes with indoles

Indium(111) bromide-catalyzed hydroarylation of alkynes with indoles leading to the synthesis of 3-vinylincloles in good to excellent yields was achieved. The E/Z ratio of the products depends on the substituents on the indole. This protocol is efficient and atom-economic from the synthetic point of view. (C) 2010 Elsevier Ltd. All rights reserved.