Solvent free oxidative radical substitution process. Synthesis of pyrrole fused systems

A xanthate-based, solvent free, homolytic substitution on selected substituted pyrrole systems is described. Additionally, a practical entry for the rapid construction of pyrrole fused systems using this solventless radical addition followed by a double nucleophilic alkylation sequence, is also reported. (C) 2010 Elsevier Ltd. All rights reserved.