期刊
TETRAHEDRON LETTERS
卷 51, 期 45, 页码 5930-5932出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.09.024
关键词
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资金
- EPSRC
- BBSRC
- GlaxoSmithKline
- Cambridge Trust
- Augustus Newman Foundation
A tetrafluorophenol acrylamide monomer unit was synthesised, co-polymerised and grafted onto a glass slide to form individual gel spots. As a proof of principle study, a small library of amides was rapidly synthesised within these gel spots using 'catch-and-release' chemistry, including the biologically interesting quorum sensing acyl-homoserine lactones. The tetrafluorophenol acrylamide gel provides an efficient platform to synthesise and screen small molecules for biological activity. (C) 2010 Elsevier Ltd. All rights reserved.
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