Synthesis of five- and six-membered lactams via solvent-free microwave Ugi reaction

Five- and six-membered lactams were synthesized via a 4-center 3-component Ugi reaction by combining amines, isocyanides, and ketoacids under solvent-free microwave conditions. The reaction was carried out in much shorter times and the yields were improved in comparison to classical conditions. (c) 2010 Elsevier Ltd. All rights reserved.