期刊
TETRAHEDRON LETTERS
卷 51, 期 52, 页码 6810-6813出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.07.066
关键词
Rubia yunnanensis; Rubiyunnanin A; Rubiyunnanin B; Cyclopeptides; Cytotoxicity; Inhibition of NO production
资金
- National Natural Science Foundation of China [30725048]
- National Basic Research Program of China [2009 CB522300]
- Science and Technology Department of Yunnan Province [2008OC011]
- State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Two novel cyclic hexapeptides, named rubiyunnanins A (1) and B (2), were isolated from the roots of Rubia yunnanensis (Franch.) Diels. Their structures were elucidated extensively by spectroscopic analysis and theoretical computation. Possible biosynthetic pathways for RAs, 1, and 2 were proposed. Compound 2 showed moderate cytotoxicities against 11 cancer cell lines and inhibited nitric oxide (NO) production in LPS and IFN-gamma-induced RAW 264.7 murine macrophages. (C) 2010 Elsevier Ltd. All rights reserved.
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