L-Proline-catalyzed one-pot expeditious synthesis of highly substituted pyridines at room temperature

Only 15 mol% of L-proline in ethanol proved to be a very efficient catalyst for the one-pot synthesis of a wide variety of highly substituted pyridines at room temperature. The methodology is mild, efficient, high yielding, and the products Call be directly recrystallized from hot ethanol. (C) 2010 Elsevier Ltd. All rights reserved.