期刊
TETRAHEDRON LETTERS
卷 51, 期 47, 页码 6169-6173出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.09.075
关键词
Peptidomimetics; Amino alkyl thiols; Carbon disulfide; Trithiocarbonates
资金
- University Grants Commission, Govt. of India, New Delhi [37-79/2009]
A simple protocol for the synthesis of a new class of trithiocarbonate-linked peptidomimetics and neoglycosylated amino acids is described. N-Protected amino alkyl thiols were treated with CS2 in the presence of triethylamine (TEA) to generate trithiocarbonate salt, which upon reaction with appropriate halides afforded dipeptidomimetics in good yields. Further, the procedure was also extended for the synthesis of N,N'-orthogonally protected trithiocarbonate-linked dipeptidomimetics. (C) 2010 Elsevier Ltd. All rights reserved.
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