'Click' synthesis of ferrocenyl-, biferrocenyl-, and cobalticenyl-triazolyl-β-cyclodextrins

Cu-I-catalyzed Huisgen-type dipolar 'click' reactions between azidomethyl-beta-cyclodextrin and ethynylferrocene, ethylnylcobaltocenium hexafluorophosphate, and bis(ethynyl)-biferrocene yield the corresponding metallocenyl-1,2,3-triazolyl-beta-cyclodextrins. The monometallocenyl 1,2,3- triazolyl-beta-cyclodextrins are soluble in water, unlike the biferrocene derivative. (C) 2010 Elsevier Ltd. All rights reserved.