期刊
TETRAHEDRON LETTERS
卷 51, 期 32, 页码 4278-4280出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.06.043
关键词
Secondary structure; Conformational analysis; Peptidomimetics; Helix; beta-Amino acids; Circular dichroism
资金
- European Commission [MEST-CT-2004-515968]
- Ministero dell'Universita e della Ricerca [2008J4YNJY]
The synthesis of two oligomers, of a bifunctional diketopiperazine scaffold DKP-1, formally derived from the cyclization of L-aspartic acid and (S)-2,3-diaminopropionic acid, is reported. A trimeric and a tetrameric structure were prepared by solution-phase peptide synthesis (Boc strategy). Conformational analysis of these derivatives was carried out by a combination of H-1 NMR spectroscopy, CD spectroscopy, and molecular modeling, and revealed the formation of beta-bend ribbon involving 10-membered H-bonded rings and a reverse turn of the growing peptide chain. (C) 2010 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据