An efficient and scalable synthesis of N-(benzyloxycarbonyl)- and N-(methyloxycarbonyl)-(S)-vinylglycinol

An efficient and scalable synthesis of N-(benzyloxycarbonyl)- and N-(methyloxycarbonyl)-(S)-vinylglycinol has been reported starting from the commercially available (L)-methionine. The scale-up preparation consisted of 5 steps and delivered up to 50 g of the desired N-protected beta-amino alcohols in 32% and 36% overall yields. (C) 2010 Elsevier Ltd. All rights reserved.