期刊
TETRAHEDRON LETTERS
卷 51, 期 23, 页码 3109-3111出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.04.020
关键词
Benzazepines; Coumarin; Benzyl amines; Catalyst-free; One-pot synthesis; Scaffold hopping; Green chemistry
资金
- ILS
A novel one-pot eco-friendly protocol for the synthesis of 2-benzazepine derivatives in water has been developed. 4-Chloro-3-formyl coumarin reacts with benzyl amines under catalyst-free conditions in aqueous medium to afford substituted 5-(2'-hydroxyaryl)-4-amido-2-benzazepines in excellent yields. (C) 2010 Elsevier Ltd. All rights reserved.
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