The first enantiospecific total synthesis of the 3-oxygenated sarpagine indole alkaloids affinine and 16-epiaffinine, as well as vobasinediol and 16-epivobasinediol

The first enantiospecific total synthesis of the 3-oxygenated sarpagine indole alkaloids affinine (1) and 16-epiaffinine (2) as well as the synthesis of vobasinediol (3) and 16-epivobasinediol (4) was accomplished from D-(+)-tryptophan methyl ester. (c) 2009 Elsevier Ltd. All rights reserved.