Mild and efficient ligand-free copper-catalyzed condensation for the synthesis of quinazolines

Condensation of o-iodobenzaldehydes la-c with amidine hydrochlorides 2a-p under ligand-free copper-catalyzed Ullmann N-arylation conditions afforded the corresponding quinazolines 3a-r in good to excellent yields. (C) 2009 Elsevier Ltd. All rights reserved.