期刊
TETRAHEDRON LETTERS
卷 51, 期 18, 页码 2461-2463出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.02.162
关键词
2-Pyridone; PPTS; Peptidomimetic; Enantioselective; Pilicide; Curlicide
资金
- Swedish Natural Research Council
- Knut and Alice Wallenberg Foundation
- JC Kempe Foundation (SJCKMS)
Improved procedures to synthesize enantioselectively analogues of a peptidomimetic scaffold with high biological relevance have been developed. Experimental design led to a general method for the preparation of dihydrooxazolo ring-fused 2-pyridones in good yields and high enantiomeric purity. The knowledge gained from this was also used to improve the microwave-accelerated synthesis of dihydrothiazolo ring-fused 2-pyridones to give complete stereo retention and high yields. (C) 2010 Elsevier Ltd. All rights reserved.
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