Pseudo four-component synthesis of benzopyranopyrimidines

An efficient and simple method for the synthesis of new benzopyranopyrimidines via a pseudo four-component reaction of salicylic aldehydes, malononitrile and various amines in the presence of a catalytic amount of LiClO(4) is reported. The advantages of this procedure are mild reaction conditions, high yields of products and operational simplicity. (C) 2010 Elsevier Ltd. All rights reserved.