期刊
TETRAHEDRON LETTERS
卷 51, 期 32, 页码 4225-4228出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.06.015
关键词
Isodon rubescens var. lushanensis; Diterpenoid; Luanchunin A; Luanchunin B
资金
- NSFC [30772637, 30830119]
- NSFC-Joint Foundation of Yunnan Province [U0832602]
- Major State Basic Research Development Program of China [2009CB522300, 2009CB940900]
- Natural Science Foundation of Yunnan Province [2008CD162]
- CAS [KSCX2-YW-R-25]
Two novel diterpenoids, luanchunins A (1) and B (2), along with their precursor, kamebakaurin (3), had been isolated from the stems and leaves of Isodon rubescens var. lushanensis. Their structures were elucidated on the basis of extensive spectroscopic analyses. Compounds 1 and 2 showed potent cytotoxic activity against HL-60 with IC50 values of 4.81 mu M and 3.52 mu M, respectively. Plausible pathways for the biosynthesis of 1 and 2 were also postulated. (C) 2010 Elsevier Ltd. All rights reserved.
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