A modular approach to catalytic synthesis using a dual-functional linker for Click and Suzuki coupling reactions

The stable benzylaziclo-boronate ester 1 is presented as an example of a dual-functional linker that allows the synthetically valuable boronate motif to be clicked onto other molecules under mild conditions. The utility of the azido-boronate motif as a modular building block is demonstrated in the rapid synthesis of drug-like structures employing sequential catalytic azide-alkyne cycloaddition and Suzuki coupling reactions. (C) 2010 Elsevier Ltd. All rights reserved.