Oxidation of 4-carboxylate thiazolines to 4-carboxylate thiazoles by molecular oxygen

A facile and environment-benign oxidation by molecular oxygen was applied for the conversion of 4-carboxylate thiazolines to 4-carboxylate thiazoles. The substituent effect on thiazoline ring was investigated. it was found that electron-poor group on the thiazoline ring could facilitate the oxidation. (C) 2010 Elsevier Ltd. All rights reserved.