期刊
TETRAHEDRON LETTERS
卷 51, 期 1, 页码 139-142出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.10.105
关键词
1-(D-Glucopyranosyl-2 '-deoxy-2 '-iminomethyl)-2-hydroxybenzene; Recognition of aromatic amino acids; Switch-on fluorescence; Computational calculations; H-bonded 1:1 complex; pi-pi interactions
资金
- DST CSIR
- DAE-BRNS
A glucose based C2-glyco-conjugate, that is, 1-(D-glucopyranosyl-2'-deoxy-2'-iminomethyl)-2-hydroxybenzene (L), has been synthesized in a high yield and characterized. Titration of L with all the 20 naturally occurring amino acids resulted in a large fluorescence intensity enhancement only in case of aromatic amino acids, that is, Phe, Trp, His, and Tyr and not with the others. This has been attributed to the initial formation of 1:1 hydrogen bonded complex followed by pi-pi interactions present between the aromatic moieties of such complexes as demonstrated by absorption and computational methods. Thus L has been able to recognize aromatic amino acids down to 1.5-3 ppm through switch-on fluorescence behavior. (C) 2009 Elsevier Ltd. All rights reserved.
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