期刊
TETRAHEDRON LETTERS
卷 51, 期 49, 页码 6436-6438出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.09.141
关键词
Biginelli reaction; 3,4-Dihydropyrimidin-2(1H)-ones; Ionic liquids; Cyclocondensation reactions; Alcohols; Oxidation
资金
- CSIR, New Delhi
An efficient of one-pot oxidative access to 3,4-dihydropyrimidin-2-(1H)-ones directly from aromatic alcohols under mild conditions is reported. The protocol involves 1-methylimidazolium hydrogen sulphate [Hmim]HSO4 catalyzed oxidation of aromatic alcohols to aromatic aldehydes with NaNO3 followed by their cyclocondensation with 1,3-dicarbonyl compounds and urea in the same reaction vessel at 80 degrees C within 2-4 h to afford 3,4-dihydropyrimidin-2-(1H)-ones in 55-97% overall yields. Thus, the present work utilizing alcohols instead of aldehyde in Biginelli reaction is a valid and green alternative to the classical synthesis of 3,4-dihydropyrimidin-2-(1H)-ones. (C) 2010 Elsevier Ltd. All rights reserved.
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