4.4 Article

The NHCs-mediated cross-coupling of aromatic aldehydes with benzyl halides: synthesis of α-aryl ketones

期刊

TETRAHEDRON LETTERS
卷 51, 期 27, 页码 3571-3574

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PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.05.003

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资金

  1. Natural Science Foundation of Shanghai [08ZR1405900]
  2. Shanghai Committee of Science and Technology [09JC1404500]
  3. '111' Project [B07023]

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A new NHCs-mediated synthetic method was found to produce alpha-aryl ketones in 22-63% yields in one-pot process from the corresponding aromatic aldehydes and benzyl halides. This method is the first example of the NHCs-mediated intermolecular nucleophilic acylation of aromatic aldehydes with benzyl halides. (C) 2010 Elsevier Ltd. All rights reserved.

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