期刊
TETRAHEDRON LETTERS
卷 50, 期 32, 页码 4658-4662出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.05.113
关键词
Diterpenoid dimer; Erythrophleum succirubrum; TRAIL-resistance overcoming activity; Cassaine
资金
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan
- Japan Science and Technology Agency Innovation Branch Chiba (JST)
Activity-guided fractionation of Erythrophleum succirubrum for TRAIL resistance-overcoming activity led to the isolation of four new cassaine diterpenoid dinners, named erythrophlesins A-D (1-4). Their structures were elucidated by spectral data to show that they have an unsymmetrical dimeric structure through an ester bond between two cassaine diterpenoids. These new compounds were revealed to have a significant reversal effect on TRAIL resistance in human gastric adenocarcinoma (AGS) cells. (C) 2009 Elsevier Ltd. All rights reserved.
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