期刊
TETRAHEDRON LETTERS
卷 50, 期 7, 页码 763-766出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.11.097
关键词
-
资金
- National Natural Science Foundation of China [20602033]
- National Basic Research Program of China [2006CB922001]
The direct palladium-catalyzed coupling reaction of indoles with alkynyl bromides was described in this paper. In the presence of catalytic amount of PdCl2(PPh3)(2) and 2.0 equiv. NaOAc, the coupling reaction of indoles with alkynyl bromides proceeded smoothly at 50 degrees C to give the corresponding 3-alkynylindoles with high regioselectivity in good to excellent yields. (C) 2008 Elsevier Ltd. All rights reserved.
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