Synthesis of indole alkaloid (-)-corynantheidol and formal synthesis of (-)-corynantheidine via one-pot asymmetric azaelectrocyclization

The highly efficient asymmetric total synthesis of indole alkaloid, (-)-corynantheidol, containing a 2,4,5-trisubstituted piperidine core, was achieved using a new version of the one-pot azaelectrocyclization reaction. The formal synthesis of (-)-corynantheidine was also achieved using the common synthetic intermediate for these corynantheines. (C) 2009 Elsevier Ltd. All rights reserved.