Asymmetric total synthesis of reported structure of eudistomidin B, an indole alkaloid isolated from a marine tunicate

Eudistomidin B, isolated from a marine tunicate, was originally assigned a tetrahydro-p-carboline structure with a 2-p-tolylethanamine residue. Asymmetric total synthesis of the reported structure of natural product, which features an intramolecular diastereoselective Pictet-Spengler cyclization, suggests that the reported structure of the natural product needs to be revised. (C) 2009 Elsevier Ltd. All rights reserved.