期刊
TETRAHEDRON LETTERS
卷 50, 期 30, 页码 4378-4380出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.05.041
关键词
Cinchona alkaloid; Ketones; Quaternary ammonium salt; Sodium hydride; Trifluoromethylation
资金
- National Natural Science Foundation of China [20732003]
- Ministry of Education [20070610019]
Enantioselective trifluoromethylation of aromatic ketones promoted by the cinchona alkaloid-derived ammonium bromide and sodium hydride was described. A series of trifluoromethyl-substituted aryl alcohols could be obtained in Lip to 82% ee with 98% yield under mild conditions. A possible catalytic cycle was also presented. (C) 2009 Elsevier Ltd. All rights reserved.
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